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Articles by M Mwamburi
PCSK9 Inhibitors - Alirocumab and Evolucumab: Key Insights on Differentiation in a Generic Market
Generic statins are the standard of care for 3 million Americans affected annually by dyslipidemia. Approximately 20% of these individuals are intolerant, and PCSK9 inhibitors provide an effective alternative. Recent drug launches (such as sofosbuvirir) have raised Payer scrutiny regarding drug pricing, triggering proactive review of therapies, such as PCSK9 inhibitors, which could pose considerable budget impact.
Assessment and Characterization of Gaps in Literature of Resource Utilization and Economic Burden in Inflammatory Myopathies
Inflammatory myopathies (IM) including polymyositis (PM), dermatomyositis (DM), and inclusion-body myositis (IBM) pose a significant burden on patients and payers. These rare diseases have no approved treatments or clinical guidelines, however their cost burden equals or exceeds that of rheumatoid arthritis and systemic sclerosis. There are significant knowledge gaps on resource utilization and cost burden in IM.
Indirect Treatment Comparison Of Newer Treatments In Relapsed / Refractory Multiple Myeloma
Relapsed / refractory multiple myeloma (rrMM) remains challenging to treat effectively. Results of two major phase III randomized controlled trials (RCTs), ASPIRE for carfilzomib and ELOQUENT-2 for elotuzumab, both in combination with lenalidomide and dexamethasone (CLD and ELD respectively) in rrMM were compared to placebo plus lenalidomide and dexamethasone (LD). We performed an indirect treatment comparison (ITC) to compare CLD versus ELD.
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