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AE adverse event AP antibiotic prophylaxis AUR acute urinary retention EAU European Association of Urology EF erectile function IIEF-5 five-item version of the International Index of Erectile Function IQR interquartile range LA local anaesthesia OR odds ratio (TP)(TR) Bx (transperineal) (transrectal) prostate biopsy(biopsies) VAS visual analogue scale Introduction The European Association of Urology (EAU) recommends transperineal prostate biopsy (TPBx) for diagnosing prostate cancer, mainly...
We thank Udit Singhal and colleagues for their Correspondence regarding our Article. 1 Jacewicz M Günzel K Rud E et al. Antibiotic prophylaxis versus no antibiotic prophylaxis in transperineal prostate biopsies (NORAPP): a randomised, open-label, non-inferiority trial. Lancet Infect Dis. 22: 1465-1471 They raise crucial questions regarding our statistical considerations during study planning.
Background The benefit of antibiotic prophylaxis is uncertain when performing transperineal prostate biopsies. Judicious use of antibiotics is required as antimicrobial resistance increases worldwide. We aimed to assess whether antibiotic prophylaxis can be omitted when performing transperineal prostate biopsies under local anaesthesia as an outpatient procedure.
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