Keywords Data sovereignty First nations Indigenous COVID-19 Self-determination OCAP® Health governance Introduction In the first two years of the COVID-19 pandemic, Canada had one of the lowest rates of COVID-19 infections and deaths per million than most in the G10 countries.1,2 However, the impact of COVID-19 was not equally distributed across the Canadian population.1 First Nations in particular experienced a significantly greater burden of disease.3–5 In 2020 and 2021, the...