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This study utilized advanced statistical methods, including propensity score, covariate adjustment, and machine learning techniques, to adjust for confounding variables within a large cohort of Brazilian inpatients. Our findings consistently demonstrated that vaccinated patients had lower rates of mortality, IMV, NIMV, dialysis, vasoactive drug use, ICU admissions, and shorter hospital lengths of stay.
The present study is part of the “Brazilian COVID-19 Registry”, a retrospective observational cohort, described in detail elsewhere [14, 15]. Temporal validation followed methodological rigor from Transparent Reporting of a Multivariable Prediction Model for Individual Prediction or Diagnosis (TRIPOD) and Prediction model Risk of Bias Assessment Tool (PROBAST) [5, 16].
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