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Malik BT

As seen in: The BMJ
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Articles by Malik BT

Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy

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By Malik BT, Byrne KT, Vella JL, Jim Middelburg
| The BMJ Verified
Method details Monospecific TA99 and Fc-silenced TA99 were generated in-house by Genmab by transfection of 293 F cells with expression vectors containing the relevant heavy and light chains.52 LALAPG mutations were introduced to the Fc domain to generate Fc-silenced TA99.53 CD3xTRP1, 4-1BBxTRP1 and B12xCD3 bsAbs were generated in-house by Genmab with controlled Fab-arm exchange using the 145-2 C11 clone recognizing CD3ε, the TA99 clone recognizing TRP1, the 3H3 clone recognizing 4-1BB and the...
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Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy

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By Byrne KT, Steinberg SM, Malik BT, Côté AL
| The BMJ Verified
Materials and methods Male and female C57BL/6 mice were purchased from Charles River Laboratory and used at 7–12 weeks of age. Pmel Thy1.1 mice (strain #005023) were purchased from The Jackson Laboratory and bred in-house. All mice were housed and used in accordance with Dartmouth’s Institutional Animal Care and Use Committee policies (IACUC Protocol #00002039).
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TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response

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By Byrne KT, Cristina Aguilar-Flores, Malik BT, Vella JL
| bmj.com
Methods This is a multicentric study involving the formation of two patient cohorts derived from the Pathology Department and/or Oncology Services of several oncology centers: Hospital de Oncología Centro Médico Nacional Siglo XXI (CMN SXXI IMSS), Hospital de Alta Especialidad 25 (IMSS), Centro Médico Nacional Manuel Ávila Camacho (IMSS), Hospital General de Zona 1A (IMSS), Centro Médico ABC, Hospital de Alta Especialidad 25 (IMSS) and Unidad Médica de Atención Ambulatoria (UMAA 199).
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