In the current issue of this journal, Zhang and colleagues provide evidence on the role of the mitochondrial fusion factor mitofusin-2 (MFN2) in the regulation of cardiometabolic adaptation in mice exposed to prolonged hypobaric hypoxia (HH), corresponding to a terrestrial altitude of 5500 m.1 They demonstrate that downregulation of MFN2 preserves myocardial function by promoting cardiac metabolic reprogramming in HH, identifying MFN2 as a novel negative regulator of high-altitude...
