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1 Introduction Curcumin is one of the most representative active constituents in the curcumin family, mainly isolated from the rhizomes of Curcuma longa L., and is currently one of the most extensively studied natural polyphenolic compounds (Esmaeli et al. 2025). Previous studies have confirmed that curcumin possesses various pharmacological activities, including antitumor, anti-inflammatory (Peng et al. 2021; Termini et al. 2020; Wang et al.
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