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Manon A. A

As seen in: Frontiers in Immunology
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Articles by Manon A. A

Frontiers | POLB 001, a p38 MAPK inhibitor, decreases local and systemic inflammatory responses following in vivo LPS administration in healthy volunteers: a randomised, double-blind, placebo-controlled study

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By de Bruin, van Schijndel, Manon A. A
| Frontiers in Immunology
Introduction Mitogen-activated protein kinases (MAPKs) are components of signalling cascades that initiate inflammatory cellular responses when activated by extracellular stimuli (1). Several subgroups of MAPKs have been identified, including p38 MAPK. Triggers for p38 MAPK activation include lipopolysaccharide (LPS) and other bacterial products, ultraviolet irradiation, hypoxia, and inflammatory cytokines (1, 2).
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