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Articles by Manuela Plate
Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1 + pathologic fibroblasts
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Fibrosis, marked by excess extracellular matrix (ECM) deposition, is the end stage of many diseases. Single-cell studies have highlighted the emergence of disease-specific fibroblast populations, including a high collagen–synthesizing CTHRC1+ subpopulation.
Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis
Abstract Fibrosis is a chronic disease characterized by excessive extracellular matrix (ECM) production which leads to destruction of normal tissue architecture and disruption of organ function. Fibroblasts are key effector cells of this process and respond to a host of pro-fibrotic stimuli, including notably the pleiotropic cytokine, TGF-β1, which promotes fibroblast to myofibroblast differentiation.
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis Online download statistics by month: Online download statistics by month: November 2020 to December 2022 AbstractFullPdf Nov 2020 1688 134 80 Dec 2020 1005 105 70 Jan 2021 517 72 57 Feb 2021 469 50 46 Mar 2021 460 59 43 Apr 2021 303 34 22 May 2021 139 39 19 Jun 2021 49 42 20 Jul 2021 36 31 15 Aug 2021 59 49 21 Sep 2021 40 31 17 Oct 2021 203 37 28 Nov 2021 299 47 21 Dec 2021 239 29 14 Jan 2022 269...
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis http://orcid.org/0000-0002-2464-6848Delphine Guillotin1, Adam R Taylor2, http://orcid.org/0000-0002-9957-0681Manuela Platé1, Paul F Mercer1, Lindsay M Edwards2, Ross Haggart3, Gino Miele3, Robin J McAnulty1, Toby M Maher4, http://orcid.org/0000-0002-2170-8791Robert E Hynds5, Mariam Jamal-Hanjani5, Richard P Marshall2, Andrew J Fisher6,7, Andy D Blanchard2,...
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis http://orcid.org/0000-0002-2464-6848Delphine Guillotin1, Adam R Taylor2, http://orcid.org/0000-0002-9957-0681Manuela Platé1, Paul F Mercer1, Lindsay M Edwards2, Ross Haggart3, Gino Miele3, Robin J McAnulty1, Toby M Maher4, http://orcid.org/0000-0002-2170-8791Robert E Hynds5, Mariam Jamal-Hanjani5, Richard P Marshall2, Andrew J Fisher6,7, Andy D Blanchard2,...
Why ERS Early Career Members should attend the International Congress 2019 in Madrid
Niki Ubags, Manuela Platé, Isaac Almendros, Sabine Bartel Breathe 2019 15: 128-130; DOI: 10.1183/20734735.0018-2019 Abstract The #ERSCongress is the largest respiratory conference worldwide. This article points out why @ERSTalk Early Career Members can especially benefit from attending this huge event and gives upcoming fellowship deadlines.
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis - Nature Communications
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Abstract Lymphangioleiomyomatosis (LAM) is a rare disease of women in which TSC2 deficient ‘LAM cells’ with dysregulated mTOR signalling and recruited fibroblasts form nodules causing lung cysts and respiratory failure. We examine if mTOR dysregulation can induce senescence and impair the response to lung injury in LAM. The senescence markers p21, p16 and the SenMayo gene set are increased in LAM lungs and colocalise with alveolar type 2 cells.
By Roya Babaei-Jadidi, Yixin Wu, Ken Chen, Manuela Plate, Kyungtae Lim, Ryan Rue, Vera P. Krymskaya, Rachel Chambers Verified, Yan Xu, Emma L. Rawlins
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Nature
Verified
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Abstract Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluation in IPF.
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq Rocio T. Martinez-Nunez, Hitasha Rupani, Manuela Platé, Mahesan Niranjan, Rachel C. Chambers, Peter H. Howarth, Tilman Sanchez-Elsner The Journal of Immunology July 1, 2018, 201 (1) 251-263; DOI: 10.4049/jimmunol.1701798
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq Rocio T. Martinez-Nunez, Hitasha Rupani, Manuela Platé, Mahesan Niranjan, Rachel C. Chambers, Peter H. Howarth, Tilman Sanchez-Elsner The Journal of Immunology May 16, 2018, ji1701798; DOI: 10.4049/jimmunol.1701798
mTOR regulates glucose metabolism during TGFβ-Induced fibroblast to myofibroblast differentiation
mTOR regulates glucose metabolism during TGF?-Induced fibroblast to myofibroblast differentiation Ilan Azuelos, Brintha Selvarajah, Ellen Forty, Manuela Plate, Gino Brunori, Lindsay Edwards, Andy Blanchard, Paul Mercer, Rachel Chambers QJM Sep 2016, 109 (suppl 1) S3-S4; DOI: 10.1093/qjmed/hcw119.003
Metabolic shift during TGF-β induced collagen synthesis
Metabolic shift during TGF-? induced collagen synthesis Brintha Selvarajah, Ilan Azuelos, Ellen Forty, Manuela Plate, Dimitrios Anastasiou, Paul Mercer, Rachel Chambers QJM Sep 2016, 109 (suppl 1) S3; DOI: 10.1093/qjmed/hcw119.002
Metabolic shift during TGF- β-induced collagen synthesis
Metabolic shift during TGF- ?-induced collagen synthesis Brintha Selvarajah, Ilan Azuelos, Ellen Forty, Manuela Plate, Dimitris Anastasiou, Paul Mercer, Rachel Chambers European Respiratory Journal Sep 2016, 48 (suppl 60) OA485; DOI: 10.1183/13993003.congress-2016.OA485
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