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Articles by Manuela Schmidt
Systematic evaluation of PASEF acquisition strategies in complex metaproteomes
Abstract Metaproteomics measures functional expression in complex microbial communities, but extreme sample complexity and dynamic range challenge acquisition strategies. Trapped ion mobility spectrometry with parallel accumulation–serial fragmentation (PASEF) has expanded into multiple acquisition modes, yet systematic evaluations in high-complexity metaproteomes remain limited.
HR Practitioners' Role in Leadership Development and Their Use of Tailoring Strategies
1 Introduction Human resource (HR) practitioners play a critical role in shaping an organization's strategic direction and aligning activities with broader organizational goals. No longer confined to administrative support, they are now recognized as strategic advisors and change agents (Finnholm et al. 2024; Örestig Kling 2024). Finnholm et al. (2024) also advocate a developmental approach combining HR expertise and innovative practices to support adaptive change.
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases - Nature Communications
Abstract The functional characterization of host-gut microbiome interactions remains limited by the sensitivity of current metaproteomic approaches. Here, we present uMetaP, an ultra-sensitive workflow combining advanced LC-MS technologies with an FDR-validated de novo sequencing strategy, novoMP.
Innovative Regional Services and Heterogeneous Communication Channels: Results from the Nationwide German egePan Project for Pandemic Management
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Ultra-sensitive metaproteomics (uMetaP) redefines the dark field of metaproteome, enables single-bacterium resolution, and discovers hidden functions in the gut microbiome
Abstract Metaproteomics uniquely characterizes host-microbiome interactions. However, most species detected by metagenomics remain hidden to metaproteomics due to sensitivity limits. We present a novel ultra-sensitive metaproteomic solution (uMetaP) that, for the first time, reaches full-length 16S rRNA taxonomic depth and can simultaneously decipher functional features.
Life situation of older people living with severe mental illness - A scoping review
INTRODUCTION The world population is ageing rapidly and the number of those over the age of 60 is expected to increase from 900 million to two billion people. As the ageing population grows, so do its mental health needs. Approximately 20% of older people (aged 60 and over) suffer from mental and neurological disorders. The increased number of older people with severe mental illness (SMI) poses additional challenges to healthcare and social services.
Achievement Goals, Student Engagement, and the Mediatory Role of Autonomy Support in Lecture-Based Courses
1. Introduction The literature on higher education recognizes that the transition from school to university can be difficult for students [1]. Issues that make this transition difficult include larger class sizes [2,3] and limited contact time with instructors perceived as a lack of support [4]. At university level, lecture-based courses are characterized by high undergraduate enrollment rates.
180° view on general practitioners’ leadership skills: practice-level comparisons of leader and staff assessments using data from the cluster-randomised controlled IMPROVEjob study
Population The baseline data of the IMPROVEjob study included 366 participants from 60 practices, consisting of 84 practice leaders, 28 employed physicians and 254 practice assistants. The mean age of the participants was 44.4 years, with a mean of 54.3 years for practice leaders, 44.8 for employed physicians and 41.0 for practice assistants. Among the practice assistants, 99.6% were women, as were 76.6% of the employed physicians and half of the practice leaders (52.4%).
IJERPH | Free Full-Text | German GPs’ Self-Perceived Role in the COVID-19 Pandemic: Leadership, Participation in Regional Services and Preferences for Future Pandemic Preparedness
4. Discussion This representative mixed-methods study provides a snapshot of GPs’ self-perceived role, leadership, participation in newly established pandemic health services, and their preferences for future regional pandemic management at around months 15 and 22 of the pandemic (shortly after nationwide vaccination campaigns started).
Call for Organizers for ICC 2025 is open
The International Cartographic Association invites bids from national members to organize the 32nd International Cartographic Conference in 2025 (ICC2025). Any member nation may lodge a bid via their national member and until the deadline: 30 June 2022, 24:00 CET Accepted bids will be made available on the ICA website. For details, please check out the Call for Organisers in English and French and the new Guidelines for Organizers.
Experiences of acute care by persons with mental health problems: An integrative literature review
Accessible summary What is known on the subject? Understanding experiences of acute care by persons with mental health problems is vital for improving these experiences through the development of different parts of the care delivery and its facilities. Literature has extensively addressed experiences of persons with mental health problems in acute care settings.
Great student maps from Project Map Creation, summer semester 2018
As in former semesters, we would like to showcase a selection of extraordinary student projects from this summer semester. The following maps are results from the class Project Map Creation. Spanish Civil War in the Basque Country by Iñigo Etxeandia Rodriguez (jpg, 2.2mb) Butterflies in Taiwan by Yuan Pei-Lun (jpg, 1,7mb) Moving Ice?
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