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We focused on individuals with extreme phenotypes of resistance to immune conversion following stimulation with Mtb-related antigens in vivo or in vitro, a clinical correlate for resistance to Mtb infection in cohort studies of exposed individuals [36, 44, 46]. We defined extreme phenotypes as negativity to TST and persistent negativity to IGRA despite high exposure due to high endemicity settings and high vulnerability due to HIV infection.
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