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Keywords JKAMP bi-allelic loss-of-function variants intellectual disability developmental delay zebrafish model endoplasmic reticulum GPR37 Get full text access Log in, subscribe or purchase for full access. References 1. Braakman, I. ∙ Hebert, D.N. Protein folding in the endoplasmic reticulum Cold Spring Harbor Perspect. Biol. 2013; 5, a013201 2. Rapoport, T.A. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes Nature. 2007; 450:663-669 3.
Abstract ADAR1 is an RNA editing enzyme which prevents autoimmunity by blocking interferon responses triggered by cytosolic RNA sensors, and is a potential target in immuno-oncology. However, predictive biomarkers for ADAR1 inhibition are lacking. Using multiple in vitro and in vivo systems, we show that BRCA1/2 and ADAR1 are synthetically lethal, and that ADAR1 activity is upregulated in BRCA1/2-mutant cancers.
Abstract The temporal control of mitotic exit of individual Schwann cells (SCs) is essential for radial sorting and peripheral myelination. However, it remains unknown when, during their multiple rounds of division, SCs initiate myelin signaling in vivo. By manipulating SC division during development, we report that when SCs skip their division during migration, but not during radial sorting, they fail to myelinate peripheral axons.
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