Introduction The glucose transporter GLUT4 has a pivotal role in facilitating glucose uptake into skeletal and cardiac muscle in response to contractions and in adipose tissue and muscle in response to insulin stimulation. It has been previously demonstrated that both a single bout of exercise (Greiwe et al. 2000; Kraniou et al. 2000, 2006; McGee and Hargreaves 2004) and regular exercise training (Gulve and Spina 1995; Houmard et al. 1995; Phillips et al. 1996; Kraniou et al.