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1 Introduction The primary approaches for treating cancer involve surgery, chemotherapy, and radiation. Chemotherapy, particularly when combined with other therapies, remains widely used and effective [1]. However, traditional nontargeted chemotherapy has its limitations and often causes systemic side effects, and cancer recurrence rates remain high [2, 3].
Abstract Smart nanogels, combining hydrogel and nanomaterial features, are promising drug carriers for cancer therapy because they can release cargo in response to tumor-related conditions. This study presents an easy, rapid synthesis of exceptionally small nanogels.
Thermosensitive microgel particles based on the polymeric network synthesized from N‐isopropylacrylamide, sodium acrylate and N,N′‐bisacryloylcystine have been functionalized with aminoferrocene, a mediatior, and a model enzyme‐glucose oxidase (GOx). The product was very stable. A thin coating of that material has been successfully attached to the glassy carbon electrode surface to form a sensing layer.
Three-segment oligonucleotide hybrids were introduced as crosslinkers to PNIPA-AAc nanonetwork. The obtained nanogels could be specifically transformed and degraded. The specific architecture of the presented carrier aims at achieving an effective cancer treatment with reduced side toxicity.
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