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Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-11070-x, published online 19 September 2017 The original version of this Article contained errors. In the original version of this Article, the authors inaccurately reported that they had measured expression of coenzyme Q10. The antibody used in the study detects COQ10B, a mitochondrial protein which interacts with coenzyme Q10 during its correct function.
In addition to degrading misfolded and damaged proteins, the proteasome regulates the fate of cells in response to stress. The role of the proteasome in pro-inflammatory cytokine-induced human beta-cell apoptosis is unknown. Using INS-1, INS-1E and human islets exposed to combinations of IFN?, IL-1? and TNF? with or without addition of small molecules, we assessed the role of the immunoproteasome in pancreatic beta-cell demise.
In addition to degrading misfolded and damaged proteins, the proteasome regulates the fate of cells in response to stress. The role of the proteasome in pro-inflammatory cytokine-induced human beta-cell apoptosis is unknown. INS-1, INS-1E and human islets were exposed to combinations of IFN?, IL-1? and TNF? with or without addition of small molecules. Gene expression was assessed by microarray or quantitative PCR. Proteasome activities were analyzed using luminescent assays.
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