1. Introduction Head and neck cancer (HNC) is the sixth most common cancer in the world. The prevalence of head and neck malignancies is mainly related to tobacco and alcohol use, which are major risk factors of these neoplasms [1]. When diagnosed, most oral cancers are already in an advanced stage, requiring more aggressive treatment. Multiple modalities are often required in the treatment of oral squamous cell carcinoma (OSCC), including major surgery, chemotherapy, and/or radiotherapy (RT) [2].
