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Disclosures of potential conflicts of interest may be found at the end of this article. In the phase III CORRECT trial, regorafenib significantly improved survival in treatment‐refractory metastatic colorectal cancer (mCRC). The CONSIGN study was designed to further characterize regorafenib safety and allow patients access to regorafenib before market authorization. This prospective, single‐arm study enrolled patients in 25 countries at 186 sites.
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