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Introduction The global rise in human life expectancy, besides extending healthy lifespan, has led to an increased prevalence of age-associated co-morbidities, including diabetes, cachexia, sarcopenia, chronic kidney disease, and many neurodegenerative diseases.
Abstract Background Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated.
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