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Vancomycin was initially dubbed “Mississippi mud” because of the brown color of early formulations, which were about 70% pure. The impurities are thought to have contributed to the incidence of adverse reactions.7,75,76 In the 1960s, purity increased to 75% and in 1985 to 92–95% for Eli Lilly’s vancomycin product.74 Concurrently, a decrease in the reporting of serious adverse events occurred.
Vancomycin was initially dubbed “Mississippi mud” because of the brown color of early formulations, which were about 70% pure. The impurities are thought to have contributed to the incidence of adverse reactions.7,75,76 In the 1960s, purity increased to 75% and in 1985 to 92–95% for Eli Lilly’s vancomycin product.74 Concurrently, a decrease in the reporting of serious adverse events occurred.
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