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Marijne Vermeer

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Articles by Marijne Vermeer

Reversal of trauma-induced monocyte paralysis by IFN-γ fails to prevent ventilator-associated pneumonia, implicating lymphoid deficits in infection risk

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By Jonas A. Schmid, Susanne Unger, Athanasios Ziogas, Stefanie Kreutmair, Maud Mayoux, Can Ulutekin, Colin Sparano, Juan Villar-Vesga, Marijne Vermeer, Selma Tuzlak, Tobias Wertheimer, Daehong Kim, Stanislav Dergun, Boris Novakovic, Laura Hurtado-Navarro, Anaísa V Ferreira, Mariolina Bruno, Marijana Matek Sarić, Philipp Häne, Cécile Poulain, Fernando P Canale, Bruno Francois, Mihai G. Netea, Antoine Roquilly, Burkhard Becher, Minqi Lin, Julien Chabbey, Amir Elalfy, Vanessa Dobernig
| Nature Verified
Abstract Ventilator-associated pneumonia (VAP) remains a frequent and severe complication in critically ill patients. Although interferon-gamma (IFN-γ) has been reported to restore trauma-associated immune defects, the PREV-HAP trial (ClinicalTrials.gov NCT04793568) did not show a benefit of IFN-γ on VAP prevention. To investigate the immunological basis of this therapeutic failure, we performed longitudinal high-dimensional immunoprofiling on 104 trial participants.
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