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ARVAMUS Meditsiini globaalsed väljakutsed. Illustratsioon: Erakogu Globaalsed tervishoiu väljakutsed on kliimamuutused, uued nakkushaigused, ravimiresistentsus jpt probleemid. Arengumaid mõjutavad ülerahvastatus, vaesus, kahjulikud elu- ja tööolud, madal vaktsineeritus jt hädad. Arenenud riikide kasvavad vajadused tulenevad elustiilihaigustest ja rahvastiku vananemisest.
1 INTRODUCTION Androgenetics describes genetic factors that impact male health and phenotypic traits, such as fertility, sexual development, male-specific cancers, and endocrine conditions. The history of androgenetics started in 1959 when Patricia Ann Jacobs and John Strong identified an extra X chromosome in men with Klinefelter syndrome originally described by Dr. Harry F.
Ethical approval All patients gave written informed consent for the analysis of their donated material and the evaluation of their clinical data compliant with local requirements. The MERGE study protocol was approved by the Münster Ethics Committees/Institutional Review Boards (Ref.
Abstract Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis of NOA has proven challenging, and the most advanced classification of NOA subforms is not based on genetics, but simple description of testis histology. In this study, we exome-sequenced over 1000 clinically diagnosed NOA cases and identified a plausible recessive Mendelian cause in 20%.
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