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Articles by Mark Carlsen
Automated Optical Treatment Based on Diffuse Reflectance Signals
1 Introduction Laser-based treatments are widely employed across modern medical disciplines, including dermatology, dentistry, oncology, and surgery, owing to their high spatial precision and minimal invasiveness [1-7]. The first major category of laser treatments involves high-energy laser irradiation that induces irreversible tissue or material changes through extreme photothermal, photo-plasmonic, and photomechanical interactions.
Unleashing precision and freedom of optical manipulation: Software-aided real-time precision opto-control of intracellular molecular activities and cell functions
Abstract The traditional method in biological science to regulate cell functions often employs chemical interventions, which commonly lack precision in space and time. While optical manipulation offers superior spatial precision, existing technologies are constrained by limitations in flexibility, accuracy, and response time.
Spatiotemporally Precise Optical Manipulation of Intracellular Molecular Activities
1 Introduction Biomolecular activities within cells exhibit intricate spatiotemporal heterogeneity. Advanced microscopy technologies have provided the means to visualize and study this heterogeneity in real time and at high spatial resolution.[1-5] However, current methods of controlling chemical processes in live cells remain rudimentary and often fail to address this heterogeneity. The prevailing approach involves incubating cells with chemical compounds that interact with molecular entities.
Spatiotemporal precise optical manipulation of intracellular molecular activities
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