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Articles by Mark Kim
From Los Angeles to Oakland, California artists celebrate Alysa Liu: 'How could we not?'
OAKLAND, Calif. -- For one muralist, it was nearly instant. For another group, it took a few days to realize Alysa Liu's golden moment in the Olympic spotlight was worthy of enshrinement. kAm%96 368:??:?8D @7 2 {@D p?86=6D\2C62 >FC2= 3J 2CE:DE vFDE2G@ +6C>6?̃@ yC][ 56A:4E:?8 2 ?@H\:4@?:4 :>286 @7 {:F 3:E:?8 96C :?5:G:5F2= 7:8FC6 D<2E:?8 8@=5 >652= 2E E96 |:=2?
"Mechanism and Rational Combinations With GP-2250, a Novel Oxathiazine " by Mark S Kim, Deanna Glassman et al.
BACKGROUND: GP-2250, a novel analog of taurultam (TRLT), has emerged as a potent anti-neoplastic drug; however, the mechanisms underlying its effects are not well understood. Here, we investigated the mechanism of action and the biological effects of GP-2250 using in vitro and in vivo models.
"Exploiting Metabolic Vulnerabilities After Anti-vegf Antibody Therapy " by Deanna Glassman, Mark S Kim et al.
Despite modest clinical improvement with anti-vascular endothelial growth factor antibody (AVA) therapy in ovarian cancer, adaptive resistance is ubiquitous and additional options are limited. A dependence on glutamine metabolism, via the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance and we aimed to investigate the utility of a GLS inhibitor (GLSi).
Mechanism and rational combinations with GP‐2250, a novel oxathiazine derivative, in ovarian cancer
1 INTRODUCTION Ovarian cancer remains the leading cause of death among all gynecological cancers.1, 2 Almost 70% of ovarian cancer patients present with advanced disease at diagnosis, and most patients die of relapsed disease by 5 years after diagnosis. The best standard therapeutic regimen for advanced ovarian cancer is cytoreductive surgery and systemic chemotherapy.
Why Firms Announce Good News Late: Earnings Management and Financial Reporting Timeliness*
* Accepted by Paul Hribar.
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