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Articles by Mark van Buchem

White Matter Lesion Progression

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By Ian Ford Verified, Thomas Lumley, Meike W Vernooij, Albert Hofman, Albert Smith, Alexa S. Beiser, Qiong Yang, Sudha Seshadri, Charles DeCarli, Philippe Amouyel, Sigurdur Sigurdsson, Vilmundur Gudnason, Joshua C. Bis, Myriam Fornage, M. Arfan Ikram, Thomas Mosley, Rebecca Gottesman, Bruce M. Psaty, Rudi Westendorp, Brendan Buckley Verified, Hieab H. H. Adams, Edith Hofer, Margherita Cavalieri, Velandai Srikanth, Stella Trompet, Benjamin F. J. Verhaaren, Christiane Wolf, Michele Callisaya, Ganesh Chauhan, Carole Dufouil, Paul Freudenberger, Gerardo Heiss, Oliver Martinez, Bernard Mazoyer, Wiro J. Niessen, Thanh Phan, Claudia L. Satizabal, Naveed Sattar, Sabrina Schilling, Dean K. Shibata, P. Eline Slagboom, David J. Stott, Russell Thomson, Anna M. Töglhofer, Christophe Tzourio, Mark van Buchem, B. Gwen Windham, Alex Zijdenbos, Richard Beare, Stéphanie Debette, J. Wouter Jukema, Lenore J. Launer, Helena Schmidt Verified, Chris Moran, Kent Taylor
| stroke.ahajournals.org
Background and Purpose—White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
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