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Articles by Markus Bosmann
The complement system: A key player in the host response to infections
Introduction According to the global disease burden statistics, infections are one of the primary causes of mortality accounting for an estimated 14 million deaths worldwide in 2019 [1]. More recently, the coronavirus disease (COVID-19) caused more than 7 million deaths [2]. These numbers underscore the staggering impact of infections on healthcare and emphasize an urgent need for a better understanding of host responses to pathogens to develop effective prevention and treatment frameworks.
Author Correction: Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling - Nature Metabolism
Correction to: Nature Metabolism https://doi.org/10.1038/s42255-023-00828-5. Published online 6 July 2023.
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling - Nature Metabolism
Abstract The gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Microbial colonization of germ-free mice dampens signaling of the intestinal Hh pathway through epithelial Toll-like receptor (TLR)-2, resulting in decreased epithelial NRP1 protein levels.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation - Nature
Author notes These authors contributed equally: Da-Yuan Chen and Chue Vin Chin Authors and Affiliations Department of Biochemistry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA Da-Yuan Chen, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway & Mohsan Saeed National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA Da-Yuan Chen, Chue Vin Chin, Devin Kenney, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, Hans P.
Complement control for COVID-19
Abstract Excessive complement activation contributes to lung disease and adverse patient outcomes in COVID-19 (see the related Research Articles by Yan et al. and Ma et al.). The complement system is an integral part of innate immune defense. It consists of about 50 proteins in plasma, on cell surfaces and inside host cells. The traditional view is that complement proteins guard the local extracellular spaces and systemic bloodstream against invading pathogens.
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