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Body weight and body composition Body weight and discrete adipose tissue pad mass were measured using a precision scale. Whole-body composition was determined using NMR imaging (EchoMRI; Echo Medical Systems). Analysis of whole-body fat depots were performed using a 7.0 T BioSpec 70/30 horizontal animal scanner (Bruker) and quantified as previously described.80 Metabolic tests Food intake was measured in acclimatized singly-housed mice using a precision scale.
Abstract Cancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved cancer treatment1. Yet, response rates are still limited, and tumour progression commonly occurs2. Soluble and cell-bound factors in the tumour microenvironment negatively affect cancer immunity.
Proteins and antibodies HIS-tagged recombinant human Growth and Differentiation Factor-15 was produced in HEK293T cells (Invigate GmbH, Jena). The anti-human GDF-15 antibody used in this manuscript was generated in female C57BL/6J GDF-15-/–mice kindly provided by Dr. Jens Strelau (Heidelberg, Germany) and validated for binding affinity by surface plasmon resonance at NMI (Reutlingen, Germany). Specificity was tested by tissue cross-reactivity studies.
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