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Articles by Markus Hilty
Identification and genetic characterization of megabase-scale plasmids of Enterobacteriaceae
Abstract Humans and animals are ubiquitously colonized by Enterobacteriaceae, including both commensals and clinically significant pathogens. Here, we report 21 complete Enterobacteriaceae megaplasmid genomes of up to 1.58 Mbp in length spanning two major clades that are highly divergent from previously described plasmids. Of these, three were reconstructed from isolates of Escherichia coli and Shigella flexneri; others were potentially hosted by species of Citrobacter and Enterobacter.
Metabolization of human milk oligosaccharides by Streptococcus pneumoniae
Abstract It is unclear whether human milk oligosaccharides (HMOs) can be used as a nutrient source by Streptococcus pneumoniae. Here, we investigate whether and how S. pneumoniae metabolizes HMOs and whether these compounds inhibit pneumococcal adherence. We find that S. pneumoniae can metabolize several HMOs, except for 2’-fucosyllactose (2’FL). The process is regulated by the carbon catabolite repression system.
The relationship between equine pastern dermatitis, meteorological factors, and the skin microbiota
Abstract en Background Equine pastern dermatitis (EPD) is a multifactorial syndrome, with prolonged exposure to moisture assumed to be a predisposing or primary factor. Hypothesis/Objectives To examine the course of EPD lesion severity, changes in bacterial skin microbiota, and the influence of meteorological factors.
The skin microbiota in equine pastern dermatitis: a case‐control study of horses in Switzerland
Abstract en Background Equine pastern dermatitis (EPD), a multifactorial syndrome, manifests as skin lesions of variable severity in the pastern area. Despite the widespread use of antibacterial therapy for treating this condition, little is known about the contributing bacteria. Hypothesis/Objectives To investigate the bacterial skin microbiota in EPD‐affected and unaffected (control) pasterns.
The influence of clinical severity and topical antimicrobial treatment on bacteriological culture and the microbiota of equine pastern dermatitis
Abstract en Background Equine pastern dermatitis (EPD) is a common dermatological problem in horses, yet its aetiology and pathogenesis are poorly understood. Objectives This study aimed to investigate the effects of lesion severity and topical antimicrobial treatment on bacterial flora of EPD‐affected skin. Animals Sixteen horses with EPD were investigated.
The influence of clinical severity and topical antimicrobial treatment on bacteriological culture and the microbiota of equine pastern dermatitis
Abstract en Background Equine pastern dermatitis (EPD) is a common dermatological problem in horses, yet its aetiology and pathogenesis are poorly understood. Objectives This study aimed to investigate the effects of lesion severity and topical antimicrobial treatment on bacterial flora of EPD‐affected skin. Animals Sixteen horses with EPD were investigated.
The Indoor-Air Microbiota of Pig Farms Drives the Composition of the Pig Farmers’ Nasal Microbiota in a Season-Dependent and Farm-Specific Manner
Environmental Microbiology Julia G. Kraemer, Susanne Aebi, Anne Oppliger, Markus Hilty Johanna Björkroth, Editor DOI: 10.1128/AEM.03038-18 ABSTRACT Prior studies have demonstrated an influence of the built environment on the human nasal microbiota. However, very little is known about the influences of working on a pig farm on the human nasal microbiota. We longitudinally collected samples from 30 pig farms (air and nasal swabs from humans and pigs) in Switzerland from 2014 to 2015.
Indoor air microbiota of pig farms drives the composition of the pig farmer's nasal microbiota in a season dependent and farm specific manner
Environmental Microbiology Julia G. Kraemer, Susanne Aebi, Anne Oppliger, Markus Hilty DOI: 10.1128/AEM.03038-18 ABSTRACT Prior studies have demonstrated an influence of the built environment on the human nasal microbiota. However, very little is known about the influences of working on a pig farm on the human nasal microbiota. We longitudinally collected samples from 30 pig farms (air, nasal swabs from humans and pigs) in Switzerland from 2014-2015.
Nasal microbiota and symptom persistence in acute respiratory tract infections in infants
Abstract Acute respiratory tract infections (ARI) in infancy have been implicated in the development of chronic respiratory disease, but the complex interplay between viruses, bacteria and host is not completely understood.
Pneumococcal carriage and serotypes distribution in patients with acute otitis media in Switzerland, 2004-2014
AbstractBackground and aims: The seven-valent (PCV7) and 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in Switzerland in 2006 and 2011, respectively. This study describes the effects of the vaccines on the pneumococcal carriage and serotype distribution in study participants with acute otitis media between 2004 and 2014.Methods: This study included nasopharyngeal swabs from participants with acute otitis media in Switzerland from 2004-2014.
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