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Articles by Markus Kipp
Conventional light microscopy or digital slides: a study to evaluate the effectiveness and acceptance of digitized histological sections in teaching
Abstract Digital learning formats are increasingly used in medical education. In histology, virtual microscopy offers a flexible alternative to conventional light microscopy, but its impact on learning outcomes and student acceptance remains debated. This study compared digital and conventional microscopy in terms of learning performance, usability, and student preferences.
Evaluation of lactic acid as a novel fixative for histological and neuroanatomical applications
Abstract Formaldehyde-based fixatives, particularly neutral-buffered formalin (NBF), are widely used in histology owing to their strong protein cross-linking capacity and reliable preservation of cytoarchitecture. However, formaldehyde is toxic and carcinogenic, motivating the search for safer alternatives. Here, we systematically evaluated lactic acid (LA) as a potential formaldehyde-free fixative for murine brain tissues.
Zellen des Nervensystems
Das Nervensystem ist kompliziert und faszinierend zugleich. In keinem anderen wissenschaftlichen Feld konnten im vergangenen Jahrzehnt größere Fortschritte verzeichnet werden als in den Neurowissenschaften. Aus klinischer Sicht stellen uns neurologische und psychiatrische Erkrankungen mitunter vor große Herausforderungen, da deren Pathogenese nur ansatzweise verstanden wird und somit bisher keine kurative Behandlung zur Verfügung steht.
The Value of Hydrogen Peroxide in Neurosurgery and Its Pathophysiological Effects in Human and Animal Brain Tissues
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
From GPT-3.5 to GPT-4.o: A Leap in AI’s Medical Exam Performance
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
How to Use the Cuprizone Model to Study De- and Remyelination
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Markus Kipp Rostock University Medical Center, Institute of Anatomy, 18057 Rostock, Germany Int. J. Mol. Sci.
Astrocytes: Lessons Learned from the Cuprizone Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases - Nature Communications
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Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative interpretation remains uncertain.
By Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Maria C. Trolese, Takashi Saito, Jack Antel, Luke Healy, Quentin Amossé, Aurélien M. Badina, Caterina Bendotti, Eleonora Aronica, Jia Wong, Anna Barron, Samuel Barnes, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet Verified, Paul Matthews, Craig Moore
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Nature
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Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Leo Heinig and Markus Kipp * Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
Ectopic Lymphoid Follicles in Progressive Multiple Sclerosis: From Patients to Animal Models
Jiangshan Zhan, Institute of Anatomy, Rostock University Medical Center, Rostock, Germany Center for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Center, Rostock, Germany Search for more papers by this author Markus Kipp, Institute of Anatomy, Rostock University Medical Center, Rostock, Germany Center for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Center, Rostock, Germany Search for more papers by this author Wenling Han,...
Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) - Teske - 2017 - Journal of Neurochemistry - Wiley Online Library
The extent of remyelination in multiple sclerosis (MS) lesions is often incomplete. Injury to oligodendrocyte progenitor cells can be a contributing factor for such incomplete remyelination. The precise mechanisms underlying insufficient repair remain to be defined, but oxidative stress appears to be involved. Here, we used immortalized oligodendrocyte cell lines as model systems to investigate a causal relation of oxidative stress and endoplasmic reticulum stress signaling cascades.
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