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2. Materials and Methods 2.1. Objectives and Endpoints The primary objective of the FLORIS study is to determine the diagnostic value of parameters for early disease detection in first-degree relatives of patients with FPF. To this end, the presence or absence of ILD changes on a baseline HRCT scan (see Figure 1) will be used to determine the predictive value for early disease of a set of clinical and exploratory parameters (see Table 1).
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