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Articles by Martin Eberhardt
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy
Discussion Aiming to discover tumor-type specific immunotherapy options, we here provide and validate an antigen selection algorithm for targeted therapies like autologous cell transfer or therapeutic antitumor vaccination. Our approach for MHC-I-restricted antigens explicitly optimizes for self-tolerance and anti-tumor immunogenicity at the selection level.
An algorithm that combines machine learning ensemble modeling and network analysis to predict self-tolerant tumor-associated antigens for anti-cancer immunotherapy
New Results doi: https://doi.org/10.1101/2023.02.09.527464 Abstract Tumor-associated antigens (TAAs) and their derived peptides constitute the chance to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. Here, we present a computational pipeline that selects and ranks candidate antigens in a multi-pronged approach and applied it to the case of uveal melanoma.
Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma
Resource Report Christopher Lischer, Martin Eberhardt, Tanushree Jaitly, Cornelia Schinzel, Niels Schaft, Jan Dörrie, Gerold Schuler and Julio Vera DOI: 10.1158/0008-5472.CAN-19-0296 Published October 2019 Abstract Therapeutic anticancer vaccination has been adapted as an immunotherapy in several solid tumors.
Curatopes Melanoma: a database of predicted T cell epitopes from overly expressed proteins in metastatic cutaneous melanoma
Resource Report Christopher Lischer, Martin Eberhardt, Tanushree Jaitly, Cornelia Schinzel, Niels Schaft, Jan Dörrie, Gerold Schuler and Julio Vera DOI: 10.1158/0008-5472.CAN-19-0296 Abstract Therapeutic anti-cancer vaccination has been adapted as an immunotherapy in several solid tumors.
An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data
An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data Pia Wentker, Martin Eberhardt, Florian S. Dreyer, Wilhelm Bertrams, Martina Cantone, Kathrin Griss, Bernd Schmeck, Julio Vera The Journal of Immunology March 1, 2017, 198 (5) 2191-2201; DOI: 10.4049/jimmunol.1502513
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