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Plasma Biomarkers for Neocortical Tau Burden Key Points Question Can additional plasma proteins enhance the diagnostic accuracy of phosphorylated tau-217 (p-tau217) for identifying advanced tau pathology? Findings In 2 independent cohorts of amyloid-β–positive individuals, a 7-protein plasma panel was associated with improved accuracy of plasma p-tau217 for differentiating advanced from early tau pathology.
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