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Mathieu Varache

As seen in: ACS Publications, BioRxiv, Dove Medical Press
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Articles by Mathieu Varache

Modification of the antibiotic, colistin, with dextrin causes enhanced cytotoxicity and triggers apoptosis in myeloid leukemia

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By Sian Rizzo, Mathieu Varache, Edward Sayers, Arwyn Jones
| BioRxiv
Abstract Acute myeloid leukemia (AML) remains difficult to treat due to its heterogeneity in molecular landscape, epigenetics and cell signaling alterations. Precision medicine is a major goal in AML therapy towards developing agents that can be used to treat patients with different 'subtypes' in combination with current chemotherapies. We have previously developed dextrin-colistin conjugates to combat the rise in multi-drug resistant bacterial infections and overcome dose-limiting nephrotoxicity.
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Colistin’s cytotoxic effects in acute myeloid leukemia

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By Sian Rizzo, Mathieu Varache, Edward Sayers, Arwyn Jones
| Dove Medical Press
Siân Rizzo,1 Mathieu Varache,1 Edward J Sayers,2 Arwyn T Jones,2 Alex Tonks,3 David W Thomas,1 Elaine L Ferguson1 1Advanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, UK; 2School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; 3Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK Correspondence: Elaine L Ferguson, Advanced Therapies Group, School of Dentistry, Cardiff University, Cardiff, UK, Tel +44 2922 510663,...
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Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo.

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By Mathieu Varache, Edward Sayers, Lucy J. Newbury, Sian Rizzo
| BioRxiv
Abstract The acute kidney injury (AKI) and dose-limiting nephrotoxicity, which occurs in 20-60% of patients following systemic administration of colistin, represents a challenge in the effective treatment of multi-drug resistant gram-negative infections.
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Polymer Masked-Unmasked Protein Therapy: Identification of the Active Species after Amylase Activation of Dextrin-Colistin Conjugates

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By Mathieu Varache, Lydia Powell, Olav A. Aarstad, Thomas Williams
| ACS Publications
1. Introduction The emergence of antibiotic-resistant bacteria represents a major global health threat and a significant clinical and societal challenge.
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