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Mathilde Keck

As seen in: Nature, Canadian Journal of Cardiology
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Articles by Mathilde Keck

Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction - Nature

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By Pierre-André Lafon, Mathilde Keck, Pierre Prieu-Sérandon, Séverine Diem, Cecile Derieux, Patrick Chames, Franck Vandermoere, Philippe Marin, Laurent Prézeau, Denis Servent, Amy J. Ramsey, Carine Bécamel, Jean-Philippe Pin, Julie Kniazeff
| Nature Verified
Abstract There is an urgent need for efficient and innovative therapies to treat brain disorders such as psychiatric and neurodegenerative diseases. Immunotherapies have proved to be efficient in many medical areas, but have not been considered to treat brain diseases due to the poor brain penetration of immunoglobulins1,2.
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QGC606, a best-in-class orally active centrally acting aminopeptidase A inhibitor prodrug, for treating heart failure following myocardial infarction

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By Mathilde Keck, Solène E. Boitard, Robin Deloux
| Canadian Journal of Cardiology Verified
ABSTRACT BACKGROUND Blockade of brain renin-angiotensin system (RAS) overactivity by firibastat, the first centrally acting aminopeptidase A (APA) inhibitor prodrug, has already demonstrated its effectiveness in improving cardiac function after myocardial infarction (MI). We developed QGC606, a more potent and more selective APA inhibitor prodrug and studied its effects after chronic oral administration in mice post-MI.
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NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

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By Hugo de Almeida, Mathilde Keck, Delphine Compère, Nicolas Inguimbert
| AHA/ASA Journals
Mathilde Keck Mathilde Keck From the Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), INSERM U1050/CNRS UMR 7241, Paris (M.K., H.D.A., D.C., A.F., C.L.-C.) Quantum Genomics, Tour Montparnasse, Paris, France (M.K., D.C., F.B.) , Hugo De Almeida Hugo De Almeida From the Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and...
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