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Abstract Click to copy section linkSection link copied! Phosphorothioate (PS) modifications in small interfering RNA (siRNA) moieties enhance stability and therapeutic efficacy, but introduce diastereomeric heterogeneity, complicating structural characterization. Conventional chromatographic methods, such as ion-pair reversed-phase liquid chromatography, provide limited resolution of complex stereoisomer systems, necessitating alternative analytical approaches.
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ppa14105-sup-0001-TableS1.xlsxExcel 2007 spreadsheet , 797.2 KB Table S1 Differentially expressed genes between Ag-Frankia versus Ag roots (uninfected treatments), Ag-Frankia-Phy versus Ag-Phy roots (infected treatment with Phytophthora alni) and Ag-Frankia versus Ag leaves (uninfected treatments). Log2(FC) = fold change. p-adjusted = p values with the Benjamin–Hochberg correction.
All reagents and solvents were purchased from commercial vendors. High-resolution mass spectra were obtained using an Agilent 6545 Q-TOF, Thermo Fisher Scientific LTQ FT Ultra, or Thermo Scientific Q Exactive HF Orbitrap-FTMS instrument. Electron impact (EI) mass spectrometry (MS) was performed on a Waters Acquity spectrometer. 1H and 13C NMR spectra were recorded on a Bruker 400 MHz and processed with the MestReNova program.
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