Abstract Preventing appointment non-adherence is critical for efficient ophthalmology clinic operations and protecting patients’ vision. This study examined patterns of cancellations and no-shows across and within comprehensive and subspecialty clinics. This cross-sectional study used multivariable logistic regression to analyse appointment records from Kensington Vision & Research Centre, Toronto, Canada, between 2013 and 2024, covering comprehensive ophthalmology and 10 subspecialties.