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Matthew Joseph

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Articles by Matthew Joseph

The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect

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By Matthew Joseph, Alexandre P.A
| Cancer Research Verified
Mutations in the tumor-suppressor gene TP53 are found in about 50% of tumors, making it the most frequently mutated gene in human cancer (1). The unusual mutational spectrum of TP53, dominated by missense mutations within p53’s central DNA-binding domain, including some hotspot mutations such as TP53R248Q, has traditionally been linked to the selection for gain-of-function properties acquired by the resulting aberrant missense mutant p53 variants (2, 3).
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The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wildtype p53 to Exert the Dominant-Negative Effect

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By Matthew Joseph, Alexandre P. A
| Cancer Research Verified
This content is only available via PDF. This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . Supplementary data
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