Research ArticleSystems Biology View ORCID ProfileAmy E. Pomeroy1,†, View ORCID ProfileMatthew I. Peña2,*,†, John R. Houser2, Gauri Dixit3, View ORCID ProfileHenrik G. Dohlman3, View ORCID ProfileTimothy C. Elston2,4,‡, and View ORCID ProfileBeverly Errede3,‡ 1Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 2Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.