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Matthew S. Jeffreys

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Articles by Matthew S. Jeffreys

Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis

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By Joshua B. McManus, Matthew S. Jeffreys, Nicole Goodwin Verified, David A. Nicewicz
| American Chemical Society
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2020, 22, 2 RETURN TO ISSUEPREVLetterNEXT Joshua B. McManus Joshua B. McManus Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States Nicholas P. R. Onuska Nicholas P. R. Onuska Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States Matthew S. Jeffreys Matthew S.
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Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

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By Paul A. Wender, Clayton T. Hardman, Stephen Ho, Matthew S. Jeffreys
| Science Magazine Verified
Scientists once accumulated 14 tons of the red, bushy, tufted sea creature Bugula neritina to extract 18 grams of bryostatin 1. The macrocyclic organic compound is under study for treatment of HIV, cancer, and Alzheimer's disease but has proven frustratingly scarce. Wender et al. report a 29-step chemical synthesis of bryostatin 1 that proceeds in 4.8% overall yield and provides gram quantities of the compound (see the Perspective by Lanman).
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