Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Matthew Wicklund
Clinical Translation of Oculopharyngeal Muscular Dystrophy Research
This is the second part of an interview with Matthew Wicklund, MD. For the first part, click here. Mutations in the PABPN1 gene, leading to abnormal protein aggregation and subsequent muscle cell degeneration, are typically the cause of oculopharyngeal muscular dystrophy (OPMD), a rare, late-onset genetic disorder characterized by progressive muscle weakness that primarily affects the muscles responsible for swallowing and eyelid movement.
OPMD and Advancements in Genetic Research
A rare, autosomal dominant disorder, the symptoms of oculopharyngeal muscular dystrophy (OPMD) include progressive weakness in muscles controlling eye movement, swallowing, and limb strength. Although some treatments focused on management of the symptoms exist, there are no currently available treatments that target the root genetic cause of the disease.
Matthew Wicklund, MD, on Clinical Translation of Oculopharyngeal Muscular Dystrophy Research
This video originally appeared on our sister site, NeurologyLive®. "This is a very smart move—a combination strategy that addresses both the abnormal and normal protein balance could redefine therapy for OPMD." A rare, late-onset genetic disorder characterized by progressive muscle weakness, oculopharyngeal muscular dystrophy (OPMD) causes progressive muscle weakness and primarily affects the muscles responsible for swallowing and eyelid movement.
Matthew Wicklund, MD, on OPMD and Advancements in Genetic Research
This video originally appeared on our sister site, NeurologyLive®. "While we don’t have definitive treatments yet for OPMD, the hope lies in emerging preclinical research and gene therapies that could one day transform how we manage this disease." Oculopharyngeal muscular dystrophy (OPMD) constitutes a rare, autosomal dominant disorder. Its symptoms include progressive weakness in muscles controlling eye movement, swallowing, and limb strength.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Matthew
Contact Matthew, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack