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Articles by Mattijs K. Julsing
Model‐Driven Engineering of Yarrowia lipolytica for Improved Microbial Oil Production
1 Introduction Plant-based oils are extensively used in food, feed, chemical, personal care and cosmetic products to enhance texture, flavour and shelf-life (Holley and Patel 2005; Desbois 2012). Palm oil, in particular, is favoured as an inexpensive source of these functional components (Rustan and Drevon 2005).
Combining metabolic engineering and fermentation optimization to achieve cost-effective oil production by Cutaneotrichosporon oleaginosus
Abstract Microbial oils, produced by oleaginous microorganisms, offer a sustainable alternative to plant-derived oils. Among these microorganisms, Cutaneotrichosporon oleaginosus attracts attention as a promising microbial cell factory for sustainable oil production due to its capacity to accumulate lipids with a similar composition to palm oil. Although C. oleaginosus can reach higher lipid contents than other oleaginous yeasts, suboptimal lipid yields and productivity limit economic feasibility.
Model-driven engineering of Yarrowia lipolytica for improved microbial oil production
Abstract Extensive usage of plant-based oils, especially palm oil, has led to environmental and social issues, such as deforestation and loss of biodiversity, thus sustainable alternatives are required. Microbial oils, especially from Yarrowia lipolytica, offer a promising solution due to their similar composition to palm oil, low carbon footprint, and ability to utilize low-cost substrates. In this study, we employed the Design-Build-Test-Learn (DBTL) approach to enhance lipid production in Y.
Model-driven engineering of Cutaneotrichosporon oleaginosus ATCC 20509 for improved microbial oil production
Abstract Consumption of plant-based oils, especially palm oil, is increasing at an alarming rate. This boosted demand for palm oil has drastic effects on the ecosystem as its production is not sustainable. C. oleaginosus is an oleaginous yeast with great potential as a source for microbial-based oil production which is a sustainable alternative to palm oil.
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