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Max Cigrang

As seen in: Nature
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Articles by Max Cigrang

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications

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By Max Cigrang, Maguelone Nogaret, Tao Ye, Pietro Berico, Gema Núñez, Emmanuel Compe, Irwin Davidson, Julian Obid
| Nature Verified
Abstract The plasticity of cancer cells facilitates their ability to adopt heterogeneous differentiation states, posing a significant challenge to therapeutic interventions. Specific gene expression programs, driven in part by super-enhancers (SEs), underlie cancer cell states. Here we successfully inhibit SE-driven transcription in phenotypically distinct metastatic melanoma cells using next-generation synthetic ecteinascidins.
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Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress - Nature Communications

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By Jadwiga Nieminuszczy, Wojciech Niedzwiedz, Giuseppina Giglia-Mari, Emmanuel Compe, Max Cigrang, Pietro Berico
| Nature Verified
Abstract The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 nuclease impairs RRS and decreases cell survival after UV irradiation, without affecting DNA repair. Overexpression of wild-type, but not nuclease-dead EXD2, restores RRS and cell survival. We observe that UV irradiation triggers the relocation of EXD2 from mitochondria to the nucleus.
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