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Articles by Max Hefti
Transplantation of a human liver following 3 days of ex situ normothermic preservation - Nature Biotechnology
Abstract Current organ preservation methods provide a narrow window (usually <12 hours) to assess, transport and implant donor grafts for human transplantation. Here we report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion. The transplanted liver exhibited normal function, with minimal reperfusion injury and the need for only a minimal immunosuppressive regimen.
Synthesis of coagulation factors during long‐term ex situ liver perfusion
MAIN TEXT ARTICLE Dilmurodjon Eshmuminov, orcid.org/0000-0002-9575-7094 Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland Wyss Zurich – ETH Zurich/University of Zurich, Zurich, Switzerland Search for more papers by this author Max Hefti, Wyss Zurich – ETH Zurich/University of Zurich, Zurich, Switzerland Transport Processes and Reactions Laboratory, Department of Mechanical and Process Engineering, ETH Zurich,...
An integrated perfusion machine preserves injured human livers for 1 week
Abstract The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation. Current approaches for normothermic perfusion can preserve human livers for only 24 h. Here we report a liver perfusion machine that integrates multiple core physiological functions, including automated management of glucose levels and oxygenation, waste-product removal and hematocrit control.
On the potential of phase-change adsorbents for CO2 capture by temperature swing adsorption
We investigate the potential of a class of recently discovered metal-organic-framework materials for their use in temperature swing adsorption (TSA) processes for CO capture; the particularity of the considered materials is their reversible and temperature dependent step-shaped CO adsorption isotherm.
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