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Abstract Immunotherapies targeting surface antigens have transformed the treatment landscape of multiple myeloma (MM), with GPRC5D emerging as a promising therapeutic target. Monoallelic loss of GPRC5D is frequently observed in newly diagnosed MM patients, and the incidence of acquired GPRC5D alterations increases following exposure to GPRC5D-directed therapies.
To the Editor Chimeric antigen receptor (CAR) T-cell therapies have significantly improved outcomes in relapsed/refractory multiple myeloma (RRMM). However, concerns are emerging regarding long-term toxicities, including prolonged cytopenias and an increased risk of secondary hematologic malignancies.
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