Key Words: Locally advanced esophageal squamous cell carcinoma chemoradiotherapy 5-fluorouracil leucovorin oxaliplatin FOLFOX plus radiation Esophageal cancer is the eighth most common type of cancer and the sixth most common cause of cancer-related deaths worldwide (1). In Japan, it is the seventh most common type of cancer and accounts for 3% of cancer-related deaths (2). Esophageal cancer has two major subtypes, namely, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma.
