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Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as Sirt1 inhibitors† Nikil Purushotham,‡a Mrityunjay Singh, ‡bc Bugga Paramesha,‡b Vasantha Kumar, a Sharad Wakode,c Sanjay K. Banerjee,§*b Boja Poojary*a and Shailendra Asthana *b Abstract Owing to its presence in several biological processes, Sirt1 acts as a potential therapeutic target for many diseases.
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