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| Scope | National, Trade/B2B |
|---|---|
| Language | English |
| Country | United States of America |
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Recent Articles
Search ArticlesThe Past, Present and Future of Lipid Nanoparticle Drug Delivery
To develop new pharmaceuticals, researchers must overcome cytotoxicity, immunogenicity, and other challenges. Lipid nanoparticle encapsulation can reduce the cytotoxicity of an active ingredient, extend circulatory availability, and take advantage of targeting strategies. Although liposomes and other lipid nanoparticles were developed early on, they remain relevant to this day. The Moderna mRNA COVID-19 vaccine is a lipid nanoparticle.
Lipid Nanoparticle Formulation and Resizing Solutions
Liposomes are generally well tolerated by the immune system and can be precisely resized to meet therapeutic needs. They, and other lipid nanoparticles are versatile nanocarriers capable of carrying hydrophobic and hydrophilic active ingredients. Researchers can tune lipid composition, introduce surface modifications, and adjust other aspects of lipid nanoparticles.
Experimental Zika Vaccine Protects Mice Through T Cells Alone
Zika virus first drew global attention in 2016, when a surge in the Americas led the World Health Organization to declare it a public health emergency of international concern, a status that held until that November. An estimated one million or more people were infected before the outbreak subsided. Doctors later linked the virus to microcephaly, miscarriage, and a cluster of birth defects now called congenital Zika syndrome.
Spatially Mapping Disease at the Lipid Level
Lipids help compose cell membranes, act as signaling molecules, and play a role in energy storage. Profiling lipid distribution, composition, and relative abundance illuminates the complex biological processes within tissues. “Metabolites and lipids offer more dynamic molecular measures of health and disease than conventional histology,” says Boone Prentice, Associate Professor in the Department of Chemistry at the University of Florida. “Lipids and metabolites are downstream, functional readouts.
Molecular Signal Directs Neutrophils to Infection without Harming Tissue
Researchers at UMass Chan Medical School and the University of Bath have identified how neutrophils, the body’s most abundant white blood cells, travel to sites of infection without harming healthy tissue along the way. The findings, published in , point to a possible new target for anti-inflammatory drugs. Neutrophils serve as the immune system’s first line of defense against microbial and viral infections.
An Introduction to Expansion Microscopy Protocols
Expansion microscopy (ExM) is an imaging technique that embeds samples within a dense, swellable hydrogel and enlarges them isotropically in three dimensions.1,2 This physical sample enlargement enables ExM to achieve a four- to five-fold linear expansion, reaching the ~60–70 nm resolution range.
Detailed Map Reveals How B Cells Behave Inside Melanoma Tumors
Researchers have built one of the most detailed maps yet of how B cells, the white blood cells responsible for making antibodies, develop and behave inside melanoma tumors. The study, led by King's College London and published in the , sheds light on how these cells develop, organize and interact within melanoma tumors before and after immunotherapy.
Standard Memory Tests Can Overlook Chemobrain Symptoms
Many women who have survived breast cancer describe ongoing memory problems after chemotherapy, often called chemobrain or brain fog. Yet the memory tests typically used in clinics, like word-pair or list-learning exercises, often fail to detect these difficulties. A new study published in is the first to directly compare a standard memory test against a story-based test built around realistic, everyday scenarios.
A Guide to High Quality Laboratory Water
Water is the most important laboratory reagent. It serves as the principal ingredient in the preparation of media, buffers, samples, dilution series, and blanks. It is also used to flush instruments, wash glassware and perform a range of routine cleaning procedures. There are different ways to purify water, and choosing a water purification system depends on the intended applications, laboratory water standards, and other factors.
Study Maps Gut Bacteria Interactions and Uncovers Cooperation Mechanisms
Understanding how bacteria influence each other is key to understanding how microbial communities take shape and persist over time. A team at Umeå University has now systematically mapped interactions between common gut bacteria, assembling one of the most comprehensive datasets of its kind. The findings, published in , show that inhibitory interactions dominate among gut bacteria, while also pointing to mechanisms through which some species help others grow.