Cell Stem Cell

Comprehensive testing of cardiac ligands within the same experiment enables precise identification of ligand-specific response genes, as differential expression analysis of each ligand can be performed versus all other ligands (STAR Methods; Figures 5A and 5B; Table S4). The ligands identified from the key clusters, including the Gαs-stimulating inotropes, endothelin, extracellular matrix regulators, and inflammatory signaling, had the most differentially expressed genes (Figure 5A).

To validate the PET probe in the clinic, we initiated an observational clinical study (platelet-derived growth factor receptor ß [PDGFRß] imaging in cardiac fibrosis - PARIS trial: https://clinicaltrials.gov/ ID: NCT06956560) in which patients with STEMI were examined 1 week and 2 months after PCI using PET in combination with magnetic resonance imaging (MRI). 68Ga-ATH001 was synthesized under GMP conditions with a radiochemical purity of 98.1% ± 0.7%.

Keywords human pluripotent stem cells high-purity dopamine progenitors Parkinson’s disease dopaminergic cell therapy clinical trial Introduction Dopaminergic (DA) cell replacement therapy has long been envisioned to move beyond symptomatic pharmacotherapy in Parkinson’s disease (PD) (Figure 1).1 The core concept is to transplant new midbrain-like DA neurons into the putamen to re-establish a more physiological and continuous DA level than can be achieved with oral levodopa, with the goal of...

Get full text access Log in, subscribe or purchase for full access. References 1. Whelan, E.C. ∙ Guo, M. ∙ Yokomizo, R. ... Generation of spermatogonia from human and non-human primate pluripotent stem cells Cell Stem Cell. 2026; ◼◼◼:◼◼◼ 2. Saitou, M. ∙ Hayashi, K. Mammalian in vitro gametogenesis Science. 2021; 374, eaaz6830 3. Sato, T. ∙ Katagiri, K. ∙ Gohbara, A. ... In vitro production of functional sperm in cultured neonatal mouse testes Nature. 2011; 471:504-507 4. Yoshino, T. ∙ Sasada, H. ∙ Sato, T. ...

ArticleOnline nowOpen access Affiliations & Notes 1Fujita Medical Innovation Center Tokyo, Fujita Health University, Tokyo, Japan 2Department of Cardiology, Keio University School of Medicine, Tokyo, Japan 3Kanagawa Institute of Industrial Science and Technology, Kawasaki, Kanagawa, Japan 4Department of Cardiovascular Surgery, Keio University School of Medicine, Tokyo, Japan 5Keio University Regenerative Medicine Research Center, Kawasaki, Kanagawa, Japan 6Center for iPS Cell Research and...

Get full text access Log in, subscribe or purchase for full access. References 1. Fliedner, T.M. ∙ Graessle, D. ∙ Paulsen, C. ... Structure and function of bone marrow hemopoiesis: Mechanisms of response to ionizing radiation exposure Cancer Biother. Radiopharm. 2002; 17:405-426 2. Iwasaki, H. ∙ Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell Immunity. 2007; 26:726-740 3. Liggett, L.A. ∙ Sankaran, V.G. Unraveling Hematopoiesis through the Lens of Genomics Cell. 2020; 182:1384-1400 4.

Keywords CAR T cell therapy liquid-liquid phase separation tonic signaling fulvestrant Get full text access Log in, subscribe or purchase for full access. References 1. Chen, Y.H. ∙ Zhang, X. ∙ Cheng, Y.F. ... Long-term follow-up of CD19 chimeric antigen receptor T-cell therapy for relapsed/refractory acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation Cytotherapy. 2020; 22:755-761 2. Hay, K.A. ∙ Gauthier, J. ∙ Hirayama, A.V. ...

STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Chicken anti-GFP Abcam ab13970; RRID: AB_300798 Goat anti-NANOG R&D Systems AF1997; RRID: AB_355097 Goat anti-SOX17 R&D SYSTEMS AF1924; RRID: AB_355060 Goat anti-CD31 R&D Systems AF3628; RRID: AB_2161028 Goat anti-DDX4 R&D Systems AF2030; RRID: AB_2277369 Goat anti-UTF1 R&D Systems AF3958; RRID: AB_2304316 Mouse anti-ACTA2 Abcam ab7817; RRID: AB_262054 Mouse anti-GFRA1 R&D Systems MAB7141; RRID: AB_2263326 Mouse anti-human...

Keywords emergency myelopoiesis hematopoietic stem and progenitor cell differentiation regeneration inflammation topology quantitative model acute myeloid leukemia Get full text access Log in, subscribe or purchase for full access. References 1. Olson, O.C. ∙ Kang, Y.A. ∙ Passegué, E. Normal hematopoiesis is a balancing act of self-renewal and regeneration Cold Spring Harb. Perspect. Med. 2020; 10, a035519 2. Swann, J.W. ∙ Olson, O.C. ∙ Passegué, E.

Keywords mesenchymal stromal cells MSCs efferocytosis cryopreservation critical quality attributes CQAs immunomodulation translational medicine dead-cell hypothesis Get full text access Log in, subscribe or purchase for full access. References 1. Phinney, D.G. Alexander Friedenstein, Mesenchymal Stem Cells, Shifting Paradigms and Euphemisms Bioengineering. 2024; 11, 534 2. Mahat, U. ∙ Przepiorka, D.