Cell Stem Cell
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Cell Stem Cell is a peer-reviewed scientific journal published by Cell Press, an imprint of Elsevier. The journal was established in 2007 and focuses on stem cell research. Both research articles and reviews are published, at about a 7 to 1 ratio. Source
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| Scope | International |
|---|---|
| Language | English |
| Country | United States of America |
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| Accepts contributed content | Yes |
Recent Articles
Search ArticlesCholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains
Differentiation of human iPSCs into neurons Neuron differentiation was adapted from Zhang et al.28 and Lam et al.29 Briefly, iPSCs were transfected with PiggyBac plasmids to confer doxycycline-inducible expression of the Neurogenin- 2 gene (NGN2, Addgene Plasmid #209077) alone or in combination with SNCA-A53T-sfGFP (Addgene Plasmid: 209080) or A53T-ΔNAC-SNCA-sfGFP (Addgene Plasmid: 209081), using LipofectamineTM Stem Transfection Reagent.
Ovarian aging and systemic health: Mechanisms and emerging intervention strategies
Keywords ovarian aging ovarian-systemic axis inflammaging interventions healthspan extension Get full text access Log in, subscribe or purchase for full access. References 1. Wang, S. ∙ Ren, J. ∙ Jing, Y. ... Perspectives on biomarkers of reproductive aging for fertility and beyond Nat Aging. 2024; 4:1697-1710 2. Liu, X. ∙ Zhao, Y. ∙ Feng, Y. ... Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body Aging Dis. 2025; 17:132-158 3. Wu, J. ∙ Wu, P. ∙ Wang, S. ...
Cardiopedia-Ligand: A ligand-receptor perturbation atlas of human cardiac organoid function and transcriptional state
Comprehensive testing of cardiac ligands within the same experiment enables precise identification of ligand-specific response genes, as differential expression analysis of each ligand can be performed versus all other ligands (STAR Methods; Figures 5A and 5B; Table S4). The ligands identified from the key clusters, including the Gαs-stimulating inotropes, endothelin, extracellular matrix regulators, and inflammatory signaling, had the most differentially expressed genes (Figure 5A).
Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
To validate the PET probe in the clinic, we initiated an observational clinical study (platelet-derived growth factor receptor ß [PDGFRß] imaging in cardiac fibrosis - PARIS trial: https://clinicaltrials.gov/ ID: NCT06956560) in which patients with STEMI were examined 1 week and 2 months after PCI using PET in combination with magnetic resonance imaging (MRI). 68Ga-ATH001 was synthesized under GMP conditions with a radiochemical purity of 98.1% ± 0.7%.
Dissecting divergent outcomes in stem cell-derived dopamine cell therapy trials for Parkinson’s disease
Keywords human pluripotent stem cells high-purity dopamine progenitors Parkinson’s disease dopaminergic cell therapy clinical trial Introduction Dopaminergic (DA) cell replacement therapy has long been envisioned to move beyond symptomatic pharmacotherapy in Parkinson’s disease (PD) (Figure 1).1 The core concept is to transplant new midbrain-like DA neurons into the putamen to re-establish a more physiological and continuous DA level than can be achieved with oral levodopa, with the goal of...
Reconstructing primate gametogenesis along its developmental trajectory
Get full text access Log in, subscribe or purchase for full access. References 1. Whelan, E.C. ∙ Guo, M. ∙ Yokomizo, R. ... Generation of spermatogonia from human and non-human primate pluripotent stem cells Cell Stem Cell. 2026; ◼◼◼:◼◼◼ 2. Saitou, M. ∙ Hayashi, K. Mammalian in vitro gametogenesis Science. 2021; 374, eaaz6830 3. Sato, T. ∙ Katagiri, K. ∙ Gohbara, A. ... In vitro production of functional sperm in cultured neonatal mouse testes Nature. 2011; 471:504-507 4. Yoshino, T. ∙ Sasada, H. ∙ Sato, T. ...
Human iPSC-derived engineered heart tissue model of diastolic dysfunction in heart failure with preserved ejection fraction
ArticleOnline nowOpen access Affiliations & Notes 1Fujita Medical Innovation Center Tokyo, Fujita Health University, Tokyo, Japan 2Department of Cardiology, Keio University School of Medicine, Tokyo, Japan 3Kanagawa Institute of Industrial Science and Technology, Kawasaki, Kanagawa, Japan 4Department of Cardiovascular Surgery, Keio University School of Medicine, Tokyo, Japan 5Keio University Regenerative Medicine Research Center, Kawasaki, Kanagawa, Japan 6Center for iPS Cell Research and...
Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level
Get full text access Log in, subscribe or purchase for full access. References 1. Fliedner, T.M. ∙ Graessle, D. ∙ Paulsen, C. ... Structure and function of bone marrow hemopoiesis: Mechanisms of response to ionizing radiation exposure Cancer Biother. Radiopharm. 2002; 17:405-426 2. Iwasaki, H. ∙ Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell Immunity. 2007; 26:726-740 3. Liggett, L.A. ∙ Sankaran, V.G. Unraveling Hematopoiesis through the Lens of Genomics Cell. 2020; 182:1384-1400 4.
FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function
Keywords CAR T cell therapy liquid-liquid phase separation tonic signaling fulvestrant Get full text access Log in, subscribe or purchase for full access. References 1. Chen, Y.H. ∙ Zhang, X. ∙ Cheng, Y.F. ... Long-term follow-up of CD19 chimeric antigen receptor T-cell therapy for relapsed/refractory acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation Cytotherapy. 2020; 22:755-761 2. Hay, K.A. ∙ Gauthier, J. ∙ Hirayama, A.V. ...
Generation of spermatogonia from human and non-human primate pluripotent stem cells
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Chicken anti-GFP Abcam ab13970; RRID: AB_300798 Goat anti-NANOG R&D Systems AF1997; RRID: AB_355097 Goat anti-SOX17 R&D SYSTEMS AF1924; RRID: AB_355060 Goat anti-CD31 R&D Systems AF3628; RRID: AB_2161028 Goat anti-DDX4 R&D Systems AF2030; RRID: AB_2277369 Goat anti-UTF1 R&D Systems AF3958; RRID: AB_2304316 Mouse anti-ACTA2 Abcam ab7817; RRID: AB_262054 Mouse anti-GFRA1 R&D Systems MAB7141; RRID: AB_2263326 Mouse anti-human...