Jun Hou Fung

Keywords emergency myelopoiesis hematopoietic stem and progenitor cell differentiation regeneration inflammation topology quantitative model acute myeloid leukemia Get full text access Log in, subscribe or purchase for full access. References 1. Olson, O.C. ∙ Kang, Y.A. ∙ Passegué, E. Normal hematopoiesis is a balancing act of self-renewal and regeneration Cold Spring Harb. Perspect. Med. 2020; 10, a035519 2. Swann, J.W. ∙ Olson, O.C. ∙ Passegué, E.

Results The stoichiometry of neurons and glia in the healthy human spinal cord was previously described,22,23 but the regulatory logic underlying cellular specification and, importantly, the programs that are requisite for transitions to altered states during disease were not assessed. We, therefore, started by characterizing cellular heterogeneity and the underlying motif activity (MA) differences between cellular subtypes in the spinal cord.

Abstract Hematopoietic stem and progenitor cells (HSPC) respond to infections, inflammation, and regenerative challenges using a collection of cellular and molecular mechanisms termed emergency myelopoiesis (EM) pathways. However, it remains unclear how various EM inducers regulate HSPCs using shared or distinct molecular mechanisms.