To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. FiguresFig. 1Primary tumour in the left lower lobe before, during and after osimertinib therapy. Consecutive CT scans demonstrating the primary tumour in the left lower lobe, adjacent to a pleural thickening and calcification caused by previous empyema. (A) Before osimertinib therapy. (B) Day 32 of osimertinib therapy, partial response. (C) Day 183, stable situation.