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[1]National Academies of Sciences, Engineering, and Medicine. “The Digital Twin Landscape”. Foundational Research Gaps and Future Directions for Digital Twins. Washington, DC: The National Academies Press; 2024. Available at: https://www.nationalacademies.org/read/26894/chapter/2 (Accessed: 28 December 2025). [2]National Academies of Sciences, Engineering, and Medicine. “The Physical Counterpart: Foundational Research Needs and Opportunities”.

[1]Akkerman AE, Kuyvenhoven MM, Verheij TJM, van Dijk L. Antibiotics in Dutch general practice: nationwide electronic GP database and national reimbursement rates. Pharmacoepidemiology and Drug Safety. 2008; 17: 378–383. https://doi.org/10.1002/pds.1501. [2]van Driel AA, Notermans DW, Meima A, Mulder M, Donker GA, Stobberingh EE, et al. Antibiotic resistance of Escherichia coli isolated from uncomplicated UTI in general practice patients over a 10-year period.

[1]Martin JA, Regehr G, Reznick R, MacRae H, Murnaghan J, Hutchison C, et al. Objective structured assessment of technical skill (OSATS) for surgical residents. The British Journal of Surgery. 1997; 84: 273–278. https://doi.org/10.1046/j.1365-2168.1997.02502.x. [2]Aghazadeh MA, Jayaratna IS, Hung AJ, Pan MM, Desai MM, Gill IS, et al. External validation of Global Evaluative Assessment of Robotic Skills (GEARS). Surgical Endoscopy. 2015; 29: 3261–3266. https://doi.org/10.1007/s00464-015-4070-8.

1. Introduction Follicular thyroid cancer (FTC) is a well-differentiated cancer of the thyroid gland, accounting for 10–15% of all thyroid cancers. FTC is characterised by follicular cell differentiation, capsular and vascular invasion. It is considered a relatively low-risk thyroid cancer with high-risk markers being tumour size, capsular and vascular invasion, distant metastases, older age at presentation and male sex [1].

[1]Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. Correction: Estimating the global burden of endemic canine rabies. PLOS Neglected Tropical Diseases. 2015; 9: e0003786. https://doi.org/10.1371/journal.pntd.0003786. [2]Tierradentro-García LO, Cortés-Albornoz MC, Talero-Gutiérrez C. Of love and other demons: depicting human rabies in Colombia. Heliyon. 2022; 8: e09703. https://doi.org/10.1016/j.heliyon.2022.e09703. [3]Jin J. Rabies. JAMA. 2023; 329: 350.

[1]Constantinescu A, Stoicescu ER, Iacob R, Chira CA, Cocolea DM, Nicola AC, et al. CT-Guided Transthoracic Core-Needle Biopsy of Pulmonary Nodules: Current Practices, Efficacy, and Safety Considerations. Journal of Clinical Medicine. 2024; 13: 7330. https://doi.org/10.3390/jcm13237330. [2]Tipaldi MA, Ronconi E, Krokidis ME, Zolovkins A, Orgera G, Laurino F, et al. Diagnostic yield of CT-guided lung biopsies: how can we limit negative sampling? The British Journal of Radiology. 2022; 95: 20210434.

[1]Löwe B, Toussaint A, Rosmalen JGM, Huang WL, Burton C, Weigel A, et al. Persistent physical symptoms: definition, genesis, and management. Lancet. 2024; 403: 2649–2662. https://doi.org/10.1016/S0140-6736(24)00623-8. [2]Haller H, Cramer H, Lauche R, Dobos G. Somatoform disorders and medically unexplained symptoms in primary care. Deutsches Arzteblatt International. 2015; 112: 279–287. https://doi.org/10.3238/arztebl.2015.0279. [3]Poloni N, Ielmini M, Caselli I, Ceccon F, Bianchi L, Isella C, et al.

We are delighted to present this video shared by Beatriz López López and Dr. Inmaculada Crespo from CES Cardenal Cisneros, in which the authors summarize the main findings of their article “Neuroplasticity in Post-Traumatic Stress Disorder (PTSD)”, published in Revista de Neurología (Volume 80, Issue 6).

1. Introduction Urticaria, a common skin disorder characterized by transient wheals and angioedema, poses a significant burden on patients’ quality of life and psychological well-being [1, 2]. The pathogenesis is mainly driven by the activation of dermal mast cells. Emerging evidence also implicates contributory roles for dysregulation of the coagulation cascade, fibrinolytic pathways, and specific autoantibodies [3, 4].

[1]Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, et al. Early palliative care and quality of life of advanced cancer patients-a multicenter randomized clinical trial. Annals of Palliative Medicine. 2019; 8: 381–389. https://doi.org/10.21037/apm.2019.02.07. [2]Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. The New England Journal of Medicine. 2010; 363: 733–742.